UNOMR

Startup Track Winner

CHF 25,000 Grant | Lab space access | Advising & mentorship

Unomr is an early-stage biotech diagnostics project from ETH providing both an interface nanopore sensor platform and AI-based data analysis for next-generation single-molecule proteomics.

Team Members: Til Schlotter, Julia Wagner, Julian Hengsteler

Learn more about their idea directly from them:

Progress during Build Phase

Read about the progress of UNOMR as they were apart of the BioIncubate program.

Bridge Proof of Concept Grant Funding

Up to CHF 130,000 awarded to Dr. Til Schlotter to continue R&D for UNOMR technology.

In March 2023, the BRIDGE Programme announced successful funding of the UNOMR project!

This program, jointly funded by SNSF and Innosuisse, empowers researchers to swiftly transform their findings into products or services.

Publication in ACS Nano

Aptamer-Functionalized Interface Nanopores Enable Amino Acid-Specific Peptide Detection

Researchers at UNOMR, the winner of our Startup Track grant, have taken a giant leap towards single-molecule proteomics. Cofounders Julian Hengsteler & Til Schlotter, in collaboration with Nako Nakatsuka, Ph.D., published this exciting paper demonstrating their technology's ability to target specific amino-acids on peptides with their aptamer-functionalized interface nanopores.

🔍 Key Breakthroughs:

🐢 Slowing down peptide movement to enhance resolution: By slowing down peptide translocation events, their integrated amino acid-specific DNA aptamers ensure single amino acid resolution is achievable.

🎯 Reducing variability in nanopore size: Their innovative approach addresses the variability in solid-state nanopore size & shape, introducing dynamically tunable pores for enhanced sensing accuracy and reproducibility.

🌐 With the possible integration of serial nanopores and additional amino acid-specific aptamers, full protein sequencing could be possible! Keep an eye on this space, setting the stage for monumental advancements in diagnostic and therapeutic application

Have a cool start-up idea yourself?

Check out more about our incubator program in the link below and prepare to rock the next edition!